The objective of the work is to evaluate the suitability of natural excipients banana powder and treated agar as disintegrant in orally disintegrating tablets (ODT). For the study purpose formulations were prepared by varying concentrations of these natural excipients and subjected to pre- and post-compression evaluations. Tablets were punched by direct compression technique. Similarity factor and dissolution efficiency methods are applied in this study for more accurate dissolution profile comparison. Pre-compression evaluation revealed that formulations containing treated agar showed excellent flow properties and compressibility than formulations with banana powder. Post compression evaluation shows increase in disintegration time and wetting time and low water absorption ratio for formulations containing banana powder than formulations containing treated agar. Dissolution profile of formulations containing treated agar showed good similarity with marketed formulation than formulations with banana powder. Treated agar when used at concentration of 40 % showed best results. It is concluded from the study that treated agar was more suitable to use as disintegrant in ODT formulations and it was also proved as a good natural excipient.
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